HNRC Investigators Present at CROI 2015

The 22nd Annual Conference on Retroviruses and Opportunistic Infections (CROI) occurs from February 23 - 26 in Seattle, Washington.

CROI brings together top basic, translational, and clinical researchers from around the world to share the latest studies, important developments, and best research methods in the ongoing battle against HIV/AIDS and related infectious diseases.

As in previous years the HNRC is well represented with rigorous and diverse findings.  See below for presentation/poster titles.  Click here to view posters if available (alphabatized by title within year - poster is icon on left hand side).

Bumpus N.  Antiretroviral drug concentrations in human brain tissue are similar or exceed historical concentrations in CSF.

Dan J.   Effect of CMV and HIV replication on T cell exhaustion and senescence during ART. 2015 Annual Conference on Retroviruses and Opportunistic Infections.

Day T, Heaton R.  Subtype associations with HIV associated neurocognitive dysfunction.

Edén A, Franklin D, Zetterberg H, Nilsson S, Fuchs D, Heaton RK, Letendre S, Marcotte T, Price RW, Grant I, Gisslén M.  CNS immunoactivation and neuronal damage in patients with progressive neurocognitive impairment.

Fazeli P, Moore DJ, Franklin DR, Heaton RK, Marra C, Gelman B, McCutchan JA, Grant I, Letendre S, for the CHARTER Group. Lower CSF Amyloid-β levels are associated with worse neurocognitive functioning in HIV-infected adults with a family history of dementia.

Gianella S, Oliveira M, Scheffler K, Strain M, De La Torre A, Letendre S, Smith D, Kosakovsky Pond S, Ellis R.  Compartmentalized HIV rebound in the CNS after ART interruption.

Gianella S, Anderson C, Var S, Oliveira M, Massanella M, Little S, Richman D, Strain M, Perez-Santiago J, Smith D.  Detectable CMV in PBMC is associated with slower HIV DNA decay during suppressive ART.

Gianella S, Smith D, Daar E, Dube M, Lisco A, Margolis L, Vanpouille C, Haubrich R, Morris S. Genital CMV Shedding Predicts Syphilis Acquisition in HIV Infected MSM on ART.

Gianella S, Scheffler K, Mehta S, Little S, Freitas L, Morris S, Smith D.  Seminal shedding of CMV and HIV transmission among men who have sex with men (MSM)

Hulgan T, Samuels D, Ellis R, Bush W, Letendre S, Franklin D, Grant I, Kallianpur A. Mitochondrial DNA haplogroups and CSF neuroinflammation in the CHARTER cohort. 

Letendre S.  Randomized clinical trial of antiretroviral therapy for prevention of HAND.

Levine AJ, Soontornniyomkij V, Achim CL, Gouaux B, Masliah E, Sinsheimer J, Singer E, Moore DJ.  Bridging genetics, histopathology, and neurocognition in the context of HAND.

Oliveira M, Gianella S, Letendre S, Scheffler K, Kosakovsky Pond S, Smith D, Strain M, Ellis R.  Highly precise measurements of HIV DNA in CSF and blood by droplet digital PCR.

Oliveira M, Murrell B, Perez-Santiago J, Vargas M, Ellis R, Letendre S, Grant I, Smith D, Woods S, Gianella S.  HIV DNA and neurocognitive impairment in older subjects on suppressive ART.

Pérez-Santiago J, De Oliveira MF, Murrell B, Var S, Day T, Woods S, Ellis R, Gianella S, Mehta S.  Mitochondrial DNA, neurologic and systemic inflammation, and immune dysregulation.

Singh K, Deng Q, Fennema-Notestine C, Vaida F, Ellis RJ, Letendre SL, Franklin D, Rosario D, Heaton RD, Grant I, and CHARTER Group.  Synergistic effects of MBL2/APP polymorphisms on neurocognitive impairment in CHARTER.

Teodorof C, Nguyen D, Kadakia N, Maung R, Soontornniyomkij B, Achim CL, Moore D, Masliah E, Kaul M, Singh K.  MBL-HIV1gp120 immunoreactivity is associated with markers of neuronal injury.

Thornton-Wells T, Fennema-Notestine C, Hulgan T, Letendre S, Ellis R, Kallianpur A, for the CHARTER Group.  Iron-Regulatory genes are associated with neuroimaging traits in HIV infection.

Var S.  Mitochondrial injury and cognitive function in HIV infection and methamphetamine use.

Vazquez-Rodriguez H.  HIV co-receptor tropism switching is correlated with binding affinity to CXCR4.

Yek C, Smith DM, Wagner GA, Morgello S, Letendre S, Grant I, Kosakovsky Pond SL, Gianella S, the CHARTER Study Group.  Suppressive ART is key to reduce neurocognitive impairment in aging HIV+ individuals.

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