HNRP Experts Invited to Participate in the HIV/AIDS Network Coordination (HANC) Behavioral Sciences Working Group
HNRP Investigators were invited to a neurocognitive assessments focus group as part of an expert panel on how neurocognitive assessments are performed, analyzed and how neurocognitive research is conducted within the NIAID HIV/AIDS Clinical Trials Networks, and other networks such as the Adolescent Trials Network. These types of working groups develop specific recommendations for community involvement in Division of AIDS-funded HIV Clinical Research Trials, based upon Best Practices document and community consultations. Drs. Ronald Ellis and Robert Heaton will participate in drafting a consensus statement for publication to guide research in this area at the focus group convening in Seattle, Washington in April 2011.
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Nadir CD4 Related to Neurocognitive Impairment
Photo of Dr. Igor Grant
Researchers from the CHARTER study found that nadir CD4 count is strongly associated with neurocognitive impairment (NCI) even after adjusting for confounding variables that can influence both nadir CD4 and NCI. This association is attenuated with combination antiretroviral therapy (CART) use, but remains present when examining only those on CART with an undetectable viral load. These findings suggest that low nadir CD4 could represent a “legacy event” in HIV infection that establishes slow or non-reversible brain damage. Prevention of severe immunosuppression may lead to more favorable neurocognitive outcomes.
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To Cite
Ellis R, Badiee J, Letendre S, Vaida F, Franklin D, Heaton R, Clifford D, Collier A, Marra C, Gelman B, McArthur J, Morgello S, Simpson D, McCutchan JA, Grant I, for the CHARTER Group. (2010). Nadir CD4 is a predictor of HIV neurocognitive impairment (NCI) in the era of combination antiretroviral therapy: results from the CHARTER Study. XVIII International AIDS Conference, July 18-23, Vienna, Austria.
Related Abstract
Heaton R, Franklin D, Ellis R, Letendre S, LeBlanc S, Woods S, Clifford D,Rivera Mindt M, Taylor M, Marcotte T, Atkinson JH, Collier A, Marra C, Gelman B, McArthur J, Morgello S,Simpson D, McCutchan JA, Grant I for the CHARTER and HNRC Groups. (2010). Increased prevalence of HIV neurocognitive impairment (NCI) among non-AIDS cases in the post-CART versus pre-CART era. XVIII International AIDS Conference, July 18-23, Vienna, Austria.
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NeuroAIDS in India Study Abstracts Presented at INS 2011
Two abstracts presented at the International Neuropsychological Society’s 39th Annual Meeting reported on data collected during the NeuroAIDS in India study . The study facilitates research that explores the prevalence and nature of HIV-associated neurocognitive impairment in HIV-infected individuals who are not on antiretroviral therapy in India.
Kamat R, Ghate M, Gollan TH, Meyer R, Vaida F, Heaton RK, Letendre S, Franklin D, Alexander T, Grant I, Mehendale S, Marcotte, TD. (2011). Effects of Marathi-Hindi bilingualism on neuropsychological performance. International Neuropsychological Society 39th Annual Meeting, Boston, Mass
Marcotte TD, Letendre SL, Meyer R, Heaton R, Alexander T, Franklin D, Kamat RK, Grant I, Mehendale S, Ghate M. (2011). Neuropsychological consequences of HIV in India. International Neuropsychological Society 39th Annual Meeting, Boston, Mass.
Davey Smith, MD, MAS Receives HIV Medicine Association’s 2010 HIV Research Award
We congratulate Davey Smith, MD, MAS, HNRC coinvestigator and head of HNRC Neurovirology Core, assistant professor of medicine in the Division of Infectious Diseases and researcher at the Antiretroviral Research Center on being awarded this special honor. He is one of two recipients of the HIV Medicine Association’s 2010 HIV Research Award, recognizing up-and-coming HIVMA members who have made outstanding contributions to HIV medicine early in their careers. He received this award at the Infectious Diseases Society of America meeting in Vancouver on October.
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