HNRP Intern Receives Dean's Award!
Alex Liu, an undergraduate at San Diego State University who is completing an internship at the HNRP under the SDSU Career Opportunities in Research (COR) program, received the Dean's Award from the SDSU College of Sciences at SDSU's 4th Annual Student Research Symposium. The award is given to the top two oral presentations in each College, regardless of undergraduate or graduate status. Alex's presentation was "Neuropsychological Functioning Predicts Occupational Attainment in an Indian Cohort," with data provided from the NeuroAIDS in India (T. Marcotte, PI) project. Alex has been invited to compete in the California State University-Wide Student Research Competition, to take place in Fresno in May.
HNRP Experts Invited to Participate in the HIV/AIDS Network Coordination (HANC) Behavioral Sciences Working Group
HNRP Investigators were invited to a neurocognitive assessments focus group as part of an expert panel on how neurocognitive assessments are performed, analyzed and how neurocognitive research is conducted within the NIAID HIV/AIDS Clinical Trials Networks, and other networks such as the Adolescent Trials Network. These types of working groups develop specific recommendations for community involvement in Division of AIDS-funded HIV Clinical Research Trials, based upon Best Practices document and community consultations. Drs. Ronald Ellis and Robert Heaton will participate in drafting a consensus statement for publication to guide research in this area at the focus group convening in Seattle, Washington in April 2011.
NeuroAIDS in India Study Abstracts Presented at INS 2011
Two abstracts presented at the International Neuropsychological Society’s 39th Annual Meeting reported on data collected during the NeuroAIDS in India study . The study facilitates research that explores the prevalence and nature of HIV-associated neurocognitive impairment in HIV-infected individuals who are not on antiretroviral therapy in India.
Kamat R, Ghate M, Gollan TH, Meyer R, Vaida F, Heaton RK, Letendre S, Franklin D, Alexander T, Grant I, Mehendale S, Marcotte, TD. (2011). Effects of Marathi-Hindi bilingualism on neuropsychological performance. International Neuropsychological Society 39th Annual Meeting, Boston, Mass
Marcotte TD, Letendre SL, Meyer R, Heaton R, Alexander T, Franklin D, Kamat RK, Grant I, Mehendale S, Ghate M. (2011). Neuropsychological consequences of HIV in India. International Neuropsychological Society 39th Annual Meeting, Boston, Mass.
Nadir CD4 Related to Neurocognitive Impairment
Photo of Dr. Igor Grant
Researchers from the CHARTER study found that nadir CD4 count is strongly associated with neurocognitive impairment (NCI) even after adjusting for confounding variables that can influence both nadir CD4 and NCI. This association is attenuated with combination antiretroviral therapy (CART) use, but remains present when examining only those on CART with an undetectable viral load. These findings suggest that low nadir CD4 could represent a “legacy event” in HIV infection that establishes slow or non-reversible brain damage. Prevention of severe immunosuppression may lead to more favorable neurocognitive outcomes.
Ellis R, Badiee J, Letendre S, Vaida F, Franklin D, Heaton R, Clifford D, Collier A, Marra C, Gelman B, McArthur J, Morgello S, Simpson D, McCutchan JA, Grant I, for the CHARTER Group. (2010). Nadir CD4 is a predictor of HIV neurocognitive impairment (NCI) in the era of combination antiretroviral therapy: results from the CHARTER Study. XVIII International AIDS Conference, July 18-23, Vienna, Austria.
Heaton R, Franklin D, Ellis R, Letendre S, LeBlanc S, Woods S, Clifford D,Rivera Mindt M, Taylor M, Marcotte T, Atkinson JH, Collier A, Marra C, Gelman B, McArthur J, Morgello S,Simpson D, McCutchan JA, Grant I for the CHARTER and HNRC Groups. (2010). Increased prevalence of HIV neurocognitive impairment (NCI) among non-AIDS cases in the post-CART versus pre-CART era. XVIII International AIDS Conference, July 18-23, Vienna, Austria.